Bonus Content
Your Daily Additives
p-Cresidine
CAS No. 120-71-8
(2-Methoxy-5-methylaniline)
p-Cresidine is used exclusively as a synthetic chemical intermediate to produce azo dyes and pigments, such as FD&C red no. 40
The dyes made with p-cresidine have been produced commercially in the United States and are used in the food and textile industries
The routes of potential human exposure to p-cresidine are inhalation, ingestion, and dermal contact.
p-Cresidine has been identified as a contaminant in FD&C red dye no. 40, which is used in gelatins, puddings, dairy products, confections, beverages, and condiments
Oral exposure to p-cresidine caused tumors at several different tissue sites in mice and rats. Dietary administration of p-cresidine caused cancer of the urinary bladder (carcinoma, including squamous-and transitional-cell carcinoma) in mice and rats of both sexes, nasal cancer (olfactory neuroblastoma) in rats of both sexes, liver cancer (hepatocellular carcinoma) in female mice, and benign liver tumors (adenoma) in male rats (NCI 1979).
A bioassay of p-cresidine for possible carcinogenicity was conducted using rats and mice. p-Cresidine was administered in the feed to groups of 50 male and 50 female animals of two different species. Low and high dose rats were 0.5 and 1.0 percent, respectively. The time-weighted average concentrations fed was 0.22, 0.22. 0.46, and 0.44 percent, respectively.
All dosed animals, except for high dose male mice, were administered p-cresidine in the diet for 104 weeks and observed for an additional period of up to 2 weeks. All high dose male mice were dead by the end of week 92. For each species, 50 animals of each sex were placed on test as controls and fed only the basal laboratory diet
Mortality rates were dose-related for both sexes of both species. That incidences of certain tumors were higher in low dose than in high dose groups was probably due to accelerated mortality in the high dose group
Causing increased incidences of carcinomas and of papillomas of the urinary bladder in both sexes, increased incidences of olfactory neuroblastomas in both sexes, and of liver tumors in males. p-Cresidine was also carcinogenic in B6C3F1 mice, causing carcinomas of the urinary bladders in both sexes and hepatocellular carcinomas in females.
NCI: (National Cancer Instiute)
Neoplastic lesions in the urinary bladder (Papilloma, Carcinoma), nasal cavity (Neuroblastoma) and liver (Neoplastic nodule or Carcinoma) Male rats; Positive
Neoplastic Lesions in the urinary bladder (Papolloma, Carcinoma), and nasal cavity (Neuroblastoma) Female rats: Positive
Neoplastic lesions in the urinary bladder (Carcinoma) Male mice: Positive
Neoplastic lesions in the urinary bladder (Carcinoma) and liver (Carcinoma) Female mice: Positive
This chemical is classified as a carcinogen. There is no acceptable exposure limit for a carcinogen.
This compound is classified as a mutagen. There is no acceptable exposure limit for a mutagen.
Acute Health Effects:
Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering.
TOXIC Effects:
Tumorigenic - Carcinogenic by RTECS criteria
Brain and Coverings - Tumors
Kidney, Ureter, and Bladder - Tumors
Liver - Tumors
Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or many human organs.
(EEC)
R23/24/25- Toxic by inhalation, in contact with skin and if swallowed.
R36/37/38- Irritating to eyes, respiratory system and skin.
R46- May cause heritable genetic damage.
R47- May cause birth defects.
https://www.spectrumchemical.com/MSDS/TCI-M0115.pdf
http://ntp.niehs.nih.gov/index.cfm?objectid=03ED0D4A-FF44-7E0F-96B289D02BA70D7A
http://ntp.niehs.nih.gov/?objectid=0704F716-D42B-27E5-EF7C87EEABF4A9BF
http://ntp.niehs.nih.gov/ntp/roc/twelfth/profiles/Cresidine.pdf
Legal G.R.A.S
http://www.law.cornell.edu/cfr/text/21/184.1
G.R.A.S. List
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